Table 2.

Controlled Trials of SAMe vs. Other Antidepressants

Trial	Year	Patients enrolled			Experimental Design	Duration (days)	SAMe dose (mg/day)	Route	Other Antidepressant	Other dose (mg/day)	Route	Primary Outcome Measure	Relative Efficacy (SAMe vs. Other)
		Total	SAMe	Other
Mantero et al.53	1975	31	16	15	double-blind	21	75	IM	Imipramine	75	IM	HAM-D	SAMe = Other
Miccoli et al.54	1978	86	45	41	double-blind	21	200	IV	Chlorimipramine or Amitryptyline	100	IV	HAM-D	SAMe = Other
Barberi et al.36	1978	20	10	10	double-blind	20	200	IV	Amitriptyline	100	IV	HAM-D	P value for comparison not provideda
Del Vecchio et al.55	1978	28	14	14	double-blind	21	150	IV	Chlorimipramine	100	IV	HAM-D	SAMe = Other
Scarzella et al.56,b	1978	20	10	10	double-blind	15	250	IV	Chlorimipramine	100	IV	HAM-D	SAMe = Other
Calandra et al.57	1979	24	12	12	no blind	15	150	IV	Chlorimipramine	100	IV	HAM-D	SAMe = Other
Monaco et al.58	1979	20	11	9	double-blind	15	200	IV	Amitriptyline	100	IV	HAM-D	SAMe = Other
Scaggion et al.59	1982	40	22	18	double-dummy	15	300	IV	Nomifensine	200	PO	HAM-D	SAMe = Other
Kufferle et al.60	1982	20	10	10	double-blind	18	150	IV	Chlorimipramine	50	IV	HAM-D	SAMe = Other
Ubago et al.61	1984	30	15	15	double-blind	30	100	IV	Chlorimipramine	50	PO	HAM-D	SAMe = Other
Bell et al.62,b	1988	22	11	11	double-dummy	14	400	IV	Imipramine	150	PO	HAM-D	SAMe > Otherc
Janicak et al.43	1988	20	12	3	double-dummy	14	400	IV	Imipramine	150	PO	HAM-D	SAMe = Other
Cerutti et al.63	1989	20	20	20	cross-over	21	800	PO	Minaprine	200	PO	HAM-D	SAMe > Otherc
Bell et al.64	1990	28	14	14	double-blind	28	1600	PO	Desipramine	250	PO	HAM-D	SAMe = Other
De Vanna et al.65,b	1992	30	15	15	double-blind	42	1600	PO	Imipramine	140	PO	MADRS	P value for comparison not provideda
Bell et al.66	1994	17	11	6	double-blind	28	1600	PO	Desipramine	250	PO	HAM-D	P value for comparison not provideda
Delle Chiale et al.50	1997	122	57	65	double-blind	21	800	IV	Chlorimipramine	100	IV	HAM-D	Other > SAMed
Delle Chiale et al.67	2000	281	143	138	double-blind	42	1600	PO	Imipramine	150	PO	HAM-D	SAMe = Other
Delle Chiale et al.67	2000	295	147	148	double-blind, dummy	28	400	IM	Imipramine	150	PO	HAM-D	SAMe = Other
Pancheri et al.68	2002	293	146	147	double-blind	28	400	IM	Imipramine	150	PO	HAM-D	SAMe = Other
Mischoulon et al.52	2014	189	64	65	double-blind, cross-over	84	1600-3200	PO	Escitalopram	10-20	PO	HAM-D	SAMe = Other

^aBoth groups demonstrated significant (p<0.05) improvements on primary outcome measure. P value for between-group comparison not provided.

^bSAMe-treated groups only. Significant (p<0.05) improvement by Day 10.

^cSAMe group demonstrated significant (p<0.05) improvement compared to other antidepressant group on primary outcome measure

^dOther antidepressant demonstrated significiant (p<0.05) improvement compared to SAMe on primary outcome measure

Abbreviations.

HAM-D, Hamilton Rating Scale for Depression

MADRS, Montgomery-Asberg's Rating Scale for Depression