Table III.

Genome-wide association study (GWAS) results for the top loci (p<1×10⁻⁶) with the GAD symptoms score, after excluding medication users

SNP	CHR	position	alleleA	alleleB	MAF	minor allele	geno.	n	Beta	SE	p-value	Location	Closest gene (<20kb)
rs78602344	6	169626581	T	C	0.115	B	G	11456	−0.27	0.05	4.18E-08	intronic	THBS2
rs141474992	4	75958947	A	C	0.006	B	I	11456	−1.04	0.20	1.83E-07
rs79812562	14	64593580	C	A	0.008	B	I	11456	−1.02	0.20	1.95E-07
rs146964092	6	39754875	A	G	0.001	B	I	11456	−2.16	0.42	1.96E-07
rs7350124	8	10625045	T	C	0.182	B	I	11455	−0.21	0.04	2.34E-07	intronic	PINX1
rs186222942	20	24548719	G	A	0.012	B	I	11456	−0.77	0.15	2.61E-07
rs11776020	8	8809696	A	G	0.455	B	G	11455	−0.17	0.03	3.26E-07
rs115013535	6	55628681	C	A	0.004	B	I	11456	−1.30	0.26	4.16E-07
rs186294317	11	20267060	G	A	0.002	B	I	11456	−1.86	0.37	4.62E-07
rs17729883	8	9256631	T	C	0.216	B	G	11455	−0.19	0.04	5.09E-07
rs189738814	10	126827710	G	A	0.004	B	I	11456	−1.50	0.30	6.02E-07
rs144369074	X	113716176	A	T	0.005	B	I	11445	−1.03	0.21	6.24E-07
rs115791358	1	64300191	A	T	0.004	B	I	11456	−1.23	0.25	7.24E-07
rs11756502	6	169633185	C	T	0.315	B	G	11456	−0.16	0.03	8.66E-07	intronic	THBS2
rs62435218	6	169642301	C	T	0.179	B	G	11456	−0.20	0.04	8.74E-07	intronic	THBS2
rs6601288	8	8943430	A	T	0.484	A	G	11455	−0.16	0.03	9.59E-07

CHR=chromosome. In the geno. (genotyping) column, G=genotyped and I=imputed. All imputed SNPs had info scores (indicating imputation quality) ≥ 0.62. AlleleA is the tested allele. Position is given in genome build GRCh37/hg19.