Table 1.
Percentage of D835 mutations in ITD+ and native FLT3 (ITD–) alleles in complementary DNA from patients who relapse on quizartinib
| Patient number | Sequences ITD+/– | Mutation | No. of ITD+/– sequences sampled | Observed alternative codon frequency of ITD+ or ITD– alleles (%) |
|---|---|---|---|---|
| 1005-006 | ITD+ | D835Y | 261 | 39.50 |
| ITD+ | D835F | 261 | 2.70 | |
| ITD– | D835Y | 564 | 16.80 | |
| 1005-007 | ITD+ | D835V | 378 | 47.40 |
| ITD+ | D835Y | 378 | 4.00 | |
| ITD– | D835V | 255 | 24.70 | |
| 1005-009 | ITD+ | D835Y | 445 | 50.60 |
| ITD– | D835Y | 10 | 50.00 | |
| 1009-003 | ITD+ | D835F | 322 | 10.60 |
| ITD+ | D835Y | 322 | 8.70 | |
| ITD+ | D835V | 322 | 3.40 | |
| ITD– | D835Y | 266 | 7.50 | |
| ITD– | D835F | 266 | 3.80 | |
| 1009-007 | ITD+ | D835Y | 235 | 55.70 |
| ITD– | D835Y | 393 | 25.20 | |
| 1011-006 | ITD+ | D835Y | 402 | 41.00 |
| ITD– | D835Y | 825 | 9.20 | |
| 1011-007 | ITD+ | D835V | 436 | 29.60 |
| ITD+ | D835Y | 436 | 3.00 | |
| ITD– | D835V | 64 | 28.10 |