. Author manuscript; available in PMC: 2018 Apr 13.

Published in final edited form as: J Med Chem. 2017 Mar 20;60(7):3109–3123. doi: 10.1021/acs.jmedchem.7b00141

Table 3.

Affinities, potencies and efficacies of adenosine derivatives for mDAT expressed in HEK-293 cells.

No.	[¹²⁵I]23 binding, EC₅₀ ± SEM (nM)	Maximal % control [¹²⁵I]23 binding	[³H]DA uptake, IC₅₀ ± SEM (nM)
1	2230 ± 430	1150 ± 60%	2290 ± 470
2	1100 ± 290	810 ± 110%	3260 ± 830
6	2760 ± 310	1000 ± 0%	4300 ± 1000
9	810 ± 270	1440 ± 190%	940 ± 130
10	1070 ± 320	1560 ± 200%	1170 ± 150
	[¹²⁵I]23 binding K_i ± SEM (nM)
Cocaine	850 ± 170	NA	200 ± 24
26	404 ± 88	NA	13.0 ± 2.6

NA, not applicable.