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. 2017 May 10;10(3):e1309488. doi: 10.1080/19420889.2017.1309488

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© 2017 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Injection of HCN4-DN(AAA) results in altered cardiac function. (A) Injecting wild-type HCN4 (HCN4-OE) into 2-cell embryos did not significantly alter heart rate. (B) Inhibiting HCN4 ion channel function (HCN4-DN[AAA]) resulted in significantly higher heart rates in all injection conditions (Welch's test, *p < 0.05). Dots represent outlier individuals who were greater or less than 1.5 times the upper and lower quartiles respectively. n = 30 embryos per condition across 3 biological replicates.