(A) Tactile responses to von Frey filaments were assessed in HFD mice receiving 2U insulin and HFD receiving 2U insulin after pretreatment with gabapentin at 200mg/kg ip. Two-way repeated measures ANOVA followed by Tukey’s post hoc test, *p<0.05, **p<0.01, ***p<0.001 vs baseline, n=7–8. (B) Blood glucose levels in HFD mice receiving 2U insulin and HFD receiving 2U insulin after pretreatment with gabapentin at 200mg/kg ip. Two-way repeated measures ANOVA followed by Tukey’s post hoc test, ***p<0.001 vs baseline, n=7–8. Mean+s.e.m.