Table 4.
Cox proportional hazards model of time to lung cancer incidence according to amount of current (study entry) physical activity and sedentary behavior.
| Incident lung cancer, current (study entry) total physical activity (MET-min/wk) | |||||
|---|---|---|---|---|---|
|
| |||||
| MET minutes per week | No. of cases | Unadjusted model
|
Adjusted model1
|
||
| HR (95% CI) | p Values | HR (95% CI) | p Values | ||
| 0 to <100 | 581 | Ref. | <0.0001 | Ref. | 0.009 |
|
| |||||
| 100 to <500 | 588 | 0.76 (0.68–0.85) | 0.86 (0.76–0.96) | ||
|
| |||||
| 500 to <1,200 | 535 | 0.68 (0.60–0.76) | 0.82 (0.73–0.93) | ||
|
| |||||
| 1,200+ | 444 | 0.72 (0.63–0.81) | 0.90 (0.79–1.03) | ||
|
| |||||
| Incident lung cancer, current (study entry) strenuous physical activity (MET-min/wk) | |||||
|
| |||||
|
Unadjusted model
|
Adjusted model1
|
||||
| MET minutes per week | No. of cases | HR (95% CI) | p Values | HR (95% CI) | Global p values |
|
| |||||
| 0 to- <100 | 1675 | Ref. | 0.04 | Ref. | 0.27 |
|
| |||||
| 100 to <500 | 155 | 0.83 (0.70–0.98) | 1.03 (0.88–1.22) | ||
|
| |||||
| 500 to <1,200 | 187 | 0.87 (0.75–1.02) | 1.04 (0.89–1.21) | ||
|
| |||||
| 1,200+ | 131 | 1.02 (0.86–1.22) | 1.20 (1.00–1.43) | ||
|
| |||||
| Incident lung cancer, current (study entry) moderate physical activity (MET-min/wk) | |||||
|
| |||||
|
Unadjusted model
|
Adjusted model1
|
||||
| MET minutes per week | No. of cases | HR (95% CI) | p Values | HR (95% CI) | Global p values |
|
| |||||
| 0 to <100 | 1,388 | Ref. | <0.0001 | Ref. | 0.01 |
|
| |||||
| 100 to <500 | 519 | 0.85 (0.77–0.94) | 0.99 (0.89–1.09) | ||
|
| |||||
| 500 to <1,200 | 185 | 0.76 (0.65–0.89) | 0.82 (0.70–0.96) | ||
|
| |||||
| 1,200+ | 56 | 1.18 (0.90–1.54) | 1.28 (0.98–1.67) | ||
|
| |||||
| Incident lung cancer, current (study entry) mild physical activity (MET-min/wk) | |||||
|
| |||||
|
Unadjusted model
|
Adjusted model1
|
||||
| MET minutes per week | No. of cases | HR (95% CI) | Global p values | HR (95% CI) | Global p values |
|
| |||||
| 0 to <100 | 1,702 | Ref. | 0.74 | Ref. | 0.65 |
|
| |||||
| 100 to <500 | 348 | 0.96 (0.86–1.08) | 0.94 (0.84–1.06) | ||
|
| |||||
| 500 to <1,200 | 84 | 1.08 (0.86–1.34) | 0.95 (0.76–1.18) | ||
|
| |||||
| 1,200+ | 14 | 0.86 (0.51–1.45) | 0.83 (0.49–1.41) | ||
|
| |||||
| Incident lung cancer, current (study entry) sedentary behavior (sitting hrs/day) | |||||
|
| |||||
|
Unadjusted model
|
Adjusted model1
|
||||
| Sitting time (hrs/day) | No. of cases | HR (95% CI) | Global p values | HR (95% CI) | Global p values |
|
| |||||
| ≤5 | 399 | Ref. | 0.01 | Ref. | 0.37 |
|
| |||||
| 6 to <10 | 571 | 1.17 (1.03–1.33) | 1.08 (0.95–1.22) | ||
|
| |||||
| ≥10 | 359 | 1.21 (1.05–1.39) | 1.10 (0.95–1.28) | ||
1
All sedentary behavior adjusted models are adjusted for age, race/ethnicity, BMI, family history of cancer, personal history of cancer, history of asthma, history of emphysema or chronic bronchitis, smoking, education, alcohol intake, vitamin D use, hormone therapy, oral contraceptive use, hysterectomy status, NSAID use, servings of fruit, vegetables, and red meat.