Table 8.
Cox proportional hazards model of time to lung cancer incidence according to amount of current (study entry) total physical activity (MET-min/wk) by lung cancer subtype
| MET minutes per week | No. of cases | Unadjusted model
|
Adjusted model*
|
||
|---|---|---|---|---|---|
| HR (95% CI) | Global p values | HR (95% CI) | Global p values | ||
| NSCLC subtype | |||||
|
| |||||
| 0 to <100 | 414 | Ref. | 0.49 | Ref. | 0.81 |
|
| |||||
| 100 to <500 | 430 | 1.02 (0.89–1.17) | 1.06 (0.92–1.22) | ||
|
| |||||
| 500 to <1,200 | 421 | 0.93 (0.81–1.07) | 1.06 (0.92–1.23) | ||
|
| |||||
| 1,200+ | 345 | 0.94 (0.82–1.09) | 1.03 (0.88–1.21) | ||
|
| |||||
| SCLC subtype | |||||
|
| |||||
| 0 to <100 | 61 | Ref. | 0.53 | Ref. | 0.53 |
|
| |||||
| 100 to <500 | 52 | 1.07 (0.73–1.56) | 1.45 (0.84–2.49) | ||
|
| |||||
| 500 to <1,200 | 39 | 0.81 (0.54–1.22) | 1.09 (0.63–1.89) | ||
|
| |||||
| 1,200+ | 38 | 1.10 (0.73–1.67) | 1.26 (0.73–2.15) | ||
|
| |||||
| NSCLC-squamous cell carcinoma | |||||
|
| |||||
| 0 to <100 | 73 | Ref. | 0.10 | Ref. | 0.16 |
|
| |||||
| 100 to <500 | 75 | 0.87 (0.63–1.21) | 0.79 (0.53–1.19) | ||
|
| |||||
| 500 to <1,200 | 56 | 0.71 (0.50–1.01) | 0.67 (0.43–1.05) | ||
|
| |||||
| 1,200+ | 37 | 0.65 (0.43–0.97) | 0.57 (0.33–0.97) | ||
|
| |||||
| NSCLC-adenocarcinoma | |||||
|
| |||||
| 0 to <100 | 202 | Ref. | 0.90 | Ref. | 0.68 |
|
| |||||
| 100 to <500 | 221 | 1.02 (0.84–1.24) | 1.13 (0.91–1.39) | ||
|
| |||||
| 500 to <1,200 | 252 | 0.96 (0.80–1.16) | 1.09 (0.88–1.34) | ||
|
| |||||
| 1,200+ | 228 | 0.97 (0.80–1.17) | 1.03 (0.83–1.28) | ||
|
| |||||
| NSCLC-other | |||||
|
| |||||
| 0 to <100 | 139 | Ref. | 0.74 | Ref. | 0.07 |
|
| |||||
| 100 to <500 | 134 | 1.12 (0.88–1.42) | 1.23 (0.95–1.60) | ||
|
| |||||
| 500 to <1,200 | 113 | 1.03 (0.80–1.32) | 1.43 (1.06–1.93) | ||
|
| |||||
| 1,200+ | 80 | 1.13 (0.85–1.48) | 1.46 (1.04–2.03) | ||