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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Acta Biomater. 2016 Dec 1;49:507–520. doi: 10.1016/j.actbio.2016.11.071

Fig. 1. Synthesis of CFEu and FA-Si-CFEu NP.

Fig. 1

The nanoparticle synthesis is illustrated in panels A and B. (A) Step-wise scheme for the synthesis of CFEu nanoparticles (Iron, coblt and europium). The particles were manufactured by a modified solvothermal technique. (Graphical descriptions of colors; Black spheres= iron; blue spheres = cobalt and red spheres = europium) (B) The steps required for entrapment of Eu3+ doped CFEu nanoparticles into core-shell Si-P407, and for decoration of Si-CFEu with FA to improve the active targeting of monocyte-macrophages are shown (Graphical descriptions of colors; Pink beads = folic acid, FA; Yellow = silica matrix, and blue = poloxamer 407).