Table 2.

Heart rate (beats/minute) and blood pressure (mmHg) at different time point (n=15 in each group)

Time point		Saline group	Low dose group	High dose Group	p value
Heart rate
1		287 ± 6	286 ± 8	274 ± 7	NS
2		281 ± 9	273 ± 9	264 ± 7	NS
3		275 ± 7	277 ± 9	267 ± 7	NS
4		280 ± 5	284 ± 6	268 ± 7	NS
5		287 ± 6	292 ±8	272 ± 9	NS
Systolic blood pressure
1		90 ± 4	90 ± 4	84 ± 3	NS
2		75 ± 2	75 ± 3	70 ± 2	NS
3		78 ± 3	84 ± 4	70 ± 2	0.037*
4		70 ± 2	84 ± 5	69 ± 3	0.016*
5		70 ± 3	76 ± 5	70 ±4	NS
Diastolic blood pressure
1		68 ± 3	70 ± 4	62 ± 3	NS
2		55 ± 2	56 ± 2	50 ± 2	NS
3		56 ± 2	62 ± 2	47 ± 2	<0.001†
4		49 ± 2	60 ± 2	46 ± 2	0.007*
5		47 ± 2	53 ± 4	45 ± 2	NS

Time point: at (1) 5 minutes prior coronary artery occlusion; (2) 1 minute prior to coronary artery reperfusion; (3) 1 hour after reperfusion; (4) 2 hours after reperfusion; (5) 3 hours after reperfusion. NS: not significant.

^*Low dose vs. high dose.

^†High dose vs. low dose and saline.