Table 1.

Activity of compounds 6a–m and 7a–m against NV 3CL protease and replicon harboring cells.

Compound	R	IC50 (μM)	EC50 (μM)	CC50 (μM)
6a	C6H5	8.5	9.5	> 100
7a		13.5	12.3	> 100
6b	(C6H5) CH2	4.5	4.1	> 100
7b		4.3	4.3	> 100
6c	(C6H5) CH2CH2	1.8	0.7	> 100
7c		2.1	0.8	> 100
6d	p-F (C6H4)	4.8	2	> 100
7d		6.2	2.1	> 100
6e	m-Cl (C6H4)	5.5	2.3	> 100
7e		5.7	1.9	> 100
6f	p-Cl (C6H4)	5.8	3.5	> 100
7f		5.1	7.2	> 100
6g	p-Cl (C6H4) CH2	1.8	2.4	> 100
7g		1.2	2.2	> 100
6h	m-Cl (C6H4) CH2CH2	2.3	1.1	> 100
7h		1.9	0.8	> 100
6i	2-Thiophene	10.4	8.5	> 100
7i		8.5	8.1	> 100
6j	Biphenyl-4-	1.3	1.3	> 100
7j		1.1	1.2	> 100
6k	2-Phthalimidoethane	2.5	2.3	> 100
7k		2.6	2.1	> 100
6l	p-CH3O(C6H4)O(CH2)3	1.8	0.2	> 100
7l		1.6	0.2	> 100
6m	CH3(CH2)7	1.2	0.3	33.8
7m		1.1	0.2	35.4