Table 5.
GMT before and 4 weeks after vaccination according to the frailty criteria
| Frailty criteria | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Weight loss | Low grip strength | Exhaustion | Low walking speed | Low physical activity | |||||||
| Vaccine strain | Yes (n = 10) | No (n = 63) | Yes (n = 39) | No (n = 34) | Yes (n = 55) | No (n = 18) | Yes (n = 37) | No (n = 36) | Yes (n = 17) | No (n = 56) | |
| A/California/7/2009 (H1N1) | Before | 16.2 | 25.5 | 23.9 | 24.0 | 21.8 | 31.7 | 23.7 | 24.2 | 20.0 | 25.3 |
| After | 121.3 | 83.6a | 93.9 | 81.6 | 81.0 | 113.1 | 72.8 | 106.8b | 90.4 | 87.2 | |
| A/Texas/50/2012 (H3N2) | Before | 30.3 | 40.4 | 42.2 | 35.4 | 41.0 | 33.0 | 41.5 | 36.3 | 38.4 | 39.0 |
| After | 65.0 | 94.4 | 93.9 | 85.0 | 98.0 | 68.6 | 110.0 | 72.7c | 55.4 | 103.7e | |
| B/Massachusetts/2/2012 | Before | 6.6 | 9.6 | 8.8 | 9.4 | 9.9 | 7.1 | 9.6 | 8.6 | 9.2 | 9.1 |
| After | 18.7 | 18.3 | 17.3 | 19.6 | 20.5 | 13.1 | 24.1 | 13.9d | 13.9 | 20.0f | |
Data are geometric mean HAI titers (GMT). “Before” refers to baseline samples (i.e. 4 weeks before vaccination) and “after” refers to 4 weeks after vaccination. P values for difference in GMT between the subjects positive or negative for the individual frailty criteria: a p = 0.02; b p = 0.07; c p = 0.03; d p = 0.01; e p = 0.001; f p = 0.06