Table 2. Multivariable Cox proportional hazard models of RFS and OS.

Variable (contrast)	Recurrence-free survival		Overall survival
	Hazard ratio	P-value	Hazard ratio	P-value
Number of positive nodes (sqrt)	2.17 (1.82, 2.60)	<0.0001	2.18 (1.82, 2.63)	<0.0001
Menopausal status (pre/post)	0.91 (0.75, 1.10)	0.3276	0.88 (0.72, 1.08)	0.2284
Dose density (q3wk/q2wk)	1.20 (0.99, 1.45)	0.0582	1.15 (0.94, 1.40)	0.1671
Sequence of therapy (con/seq)	0.98 (0.81, 1.18)	0.8314	0.98 (0.80, 1.19)	0.8174
PAM50 intrinsic subtype
Basal-like versus LumA	1.83 (1.40, 2.38)	<0.0001	1.91 (1.44, 2.53)	<0.0001
HER2-E versus LumA	1.63 (1.24, 2.15)		1.69 (1.27, 2.26)
LumB versus LumA	1.47 (1.14, 1.91)		1.47 (1.12, 1.94)

Abbreviations: con, concurrent; HER2-E, HER2-enriched; Lum, luminal; q2wk, every two weeks or 2-weekly; q3wk, every 3 weeks or 3-weekly; seq, sequential; sqrt, square root.

N=1,299 because 11 patients were missing information about the number of positive nodes or menopausal status.