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. 2017 May 18;35(20):2268–2278. doi: 10.1200/JCO.2016.70.7059

Fig 2.

Fig 2.

Subtype combinations of KIR3DL1 and HLA-Bw4 predict differential inhibition and killing of leukemia target cells. Peripheral blood mononuclear cells (PBMCs) were cultured with Bw4 subtype-matched target cells for 48 hours and the viability of leukemia cells was measured thereafter. (A) Cytotoxicity of the Bw4-80T+ acute myelogenous leukemia (AML) cell line SET-2 by PBMCs from Bw4-80T+ donors. (B) Cytotoxicity of the Bw4-80I+ AML cell line KG-1 by PBMCs from Bw4-80I+ donors. (C) Cytotoxicity of the Bw4-80T+ AML cell line SET-2 by PBMCs from Bw4-80T+ donors in the presence of Z27 antibody. (D) Cytotoxicity of the Bw4-80I+ AML cell line KG-1 by PBMCs from Bw4-80I+ donors in the presence of Z27 antibody. All bars represent means ± standard error of the mean. Each bar represents a minimum of six independent healthy donors and HLA-C subtype groups are stratified equivalently between groups.