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. 2017 May 18;35(20):2268–2278. doi: 10.1200/JCO.2016.70.7059

Fig 5.

Fig 5.

KIR3DL1 and HLA-B subtype combinations predict a spectrum of post-transplant outcomes. Relative hazards were calculated by Cox proportional hazards regression analysis to compare the impacts of donor and recipient HLA-B. (A) Overall relapse and (B) mortality among hematopoietic cell transplantation (HCT) pairs with specific donor KIR3DL1 and HLA-B subtype combinations are shown. (C) Relapse and (D) mortality segregated by recipient HLA-B subtype (Bw6, Bw4-80T, or Bw4-80I) stratified by donor KIR3DL1 subtypes (KIR3DL1-N, -L, or -H) are shown. Diamonds (◇) represent KIR3DL1-N donors, triangles (△) represent KIR3DL1-L donors, and circles (○) represent KIR3DL1-H donors. Open blue, yellow, and gray symbols represent donor-recipients who encode Bw6, Bw4-80T, or Bw4-80I, respectively, and the numbers of donor-patient pairs in each compound subgroup are shown. Relative hazards reflect adjustment for patient’s age, conditioning regimen, T-cell depletion, graft type, disease status, and cytomegalovirus and gender match. The legend indicates the number of patients present in each subgroup assessed.