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. 2017 May 18;35(20):2268–2278. doi: 10.1200/JCO.2016.70.7059

Fig A3.

Fig A3.

Donors who were heterozygous for KIR3DL1-l+h exhibit cytotoxicity most similar to KIR3DL1-L. (A) Cytotoxicity of the Bw4-80T+ acute myelogenous leukemia (AML) cell line SET-2 by peripheral blood mononuclear cells (PBMCs) from Bw4-80T+ healthy donors coexpressing KIR3DL1-l and KIR3DL1-h (l+h) or exhibiting only one of either KIR3DL1-h or KIR3DL1-l. (B) Cytotoxicity of the Bw4-80I+ AML cell line KG-1 by PBMCs from healthy Bw4-80I+ donors coexpressing KIR3DL1-l and KIR3DL1-h (l+h) or exhibiting only one of either KIR3DL1-h (H) or KIR3DL1-l (L). Bars represent means ± standard error of the mean and a minimum of seven independent donors and three independent trials. Means are compared by one-way ANOVA using Tukey’s post hoc test.