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. 2017 Jul 7;12(7):e0179835. doi: 10.1371/journal.pone.0179835

Fig 6. AMPKα signaling is critical for the mediation of STAT3 influence on hypertrophy.

Fig 6

(A) WP1066 and AICAR treatment for 48 h suppressed Ang II-induced ANP and β-MHC mRNA expression. Data represent mean ± SEM (n = 4); *P<0.01 vs. Control; †P<0.01 vs. Ang II alone; #P<0.01 vs. Ang II + WP1066; §P<0.05 vs. Ang II + AICAR. (B) Inhibition of AMPK with Compound C reversed the suppression of hypertrophy marker expression by WP1066 following Ang II treatment of H9c2 cells. Data represent mean ± SEM (n = 4); *P<0.01 vs. Control; †P<0.01 vs. Ang II alone; #P<0.01 vs. Ang II + WP1066; and §P<0.05 vs. Ang II + Compound C.