Table 2. Plasma pharmacokinetic parameters of PTX after intravenous administration of Taxol and DEX-IND/PTX micelles in rats (n = 5).
Parameters | Formulations | |
---|---|---|
Taxol | DEX-IND/PTX | |
AUC0-∞/ng·mL-1·h-1 | 99.71 ± 19.347 | 300.069 ± 89.089 |
MRT0-∞/h | 7.936 ± 1.06 | 13.234 ±11.175 |
CL/L·h-1·kg-1 | 0.103 ± 0.019 | 0.036 ± 0.011 |
AUC, area under the concentration-time curve; MRT, mean residence time; CL, clearance rate.