Table 1. Body weight, food intake, and biochemical parameters in an animal model of chronic kidney disease.
| LP | Adenine | AG10 | AG20 | |
|---|---|---|---|---|
| Body weight (g) | 400±6.83 | 244±13.50* | 247±5.41* | 261±10.91* |
| Food intake (g/day) | 25.8±0.69 | 7.2±1.28* | 6.7±1.04* | 6.7±1.09* |
| BUN (mg/dL) | 8.42±0.96 | 183.63±45.05* | 107.0±14.26*# | 113.08±22.40*# |
| Creatinine (mg/dL) | 0.44±0.03 | 3.35±0.48* | 2.95±0.37* | 2.90±0.51* |
| Calcium (mg/dL) | 9.44±0.09 | 9.13±0.58 | 9.45±0.42 | 9.22±0.21 |
| Phosphate (mg/dL) | 5.66±0.36 | 21.73±2.26* | 19.73±1.90* | 19.24±1.14* |
| Glucose (mg/dL) | 118±9.9 | 110±17.2 | 110±13.5 | 90.4±8.2 |
LP, low protein; AG10, adenine-gemigliptin (10 mg/kg) group; AG20, adenine-gemigliptin (20mg/kg) group; and BUN, blood urea nitrogen.
*P<0.001 compared with low protein group and
#P<0.001 compared with adenine group.