Fig 2. Levels of soluble E-selectin and soluble ICAM-1 are increased during the acute phase of human leptospirosis.

Levels of soluble (shed) adhesion molecules are determined in patients and controls using multiplex microbeads array. Circles represent controls (n = 10), empty triangles: patients during acute phase (n = 20) and black triangles: patients at M1 convalescent phase (n = 10). The largest horizontal bars indicate the median value, upper and lower bars the interquartile ranges. Comparisons with non-parametric Mann-Whitney test. *, **, **** indicate P-value inferior to 0.05, 0.01 and 0.0001 respectively.