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. 2017 Jul 7;12(7):e0180485. doi: 10.1371/journal.pone.0180485

Table 2. Rare missense alleles predicted to be damaging and benign in 237 neuronal excitability genes.

    Damaging Benign
Gene Class # Genes Mild Severe Mild Severe
Cholinergic Receptor Genes 16 3 4 2 3
Dopamine Receptor Genes 5 0 0 2 2
GABA Receptor Genes 20 0 5 3 5
Glycine Receptor Genes 9 0 0 1 0
Ionotropic Glutamate Receptor Genes 14 0 3 1 1
Metabotropic Glutamate Receptor Genes 8 1 3 1 1
Serotonin Receptor Genes 16 3 3 3 3
Voltage-gated Calcium Channel Genes 26 0 6 3 8
Chloride Channel Genes 9 2 1 4 4
Voltage-gated Potassium Channel Genes 50 5 9 5 5
Voltage-gated Sodium Channel Genes 14 1 2 4 7
Calcium Activated Potassium Channel Genes 8 0 0 0 2
Potassium Inwardly Rectifiying Channel Genes 14 2 4 1 0
Twin Pore Potassium Channel Genes 14 0 0 1 1
Cyclic Nucleotide-gated Channel Genes 4 0 1 0 1
Ryanodine Receptor Genes 3 1 4 4 3
Other 7 0 1 0 2