Table 3. Associations between remaining CAD-related SNPs and inflammatory proteins.
| Locus | SNP | Nearby genes | Call rate (%) |
RAF | hs-CRP Beta (95% CI) |
p | IL-6 Beta (95% CI) |
p | Calprotectin Beta (95% CI) |
p | Fibrinogen Beta (95% CI) |
p | C3 Beta (95% CI) |
p |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6p21.2 | rs10947789 | KCNK5 | 100 | 0.80 | 0.10 (-0.09–0.29) | 0.29 | -0.23 (-0.92–0.46) | 0.51 | 0.00 (-0.09–0.09) | 0.95 | 0.01 (-0.12–0.15) | 0.85 | 0.01 (-0.03–0.04) | 0.68 |
| 7q22 | rs10953541 | BCAP29 | 100 | 0.76 | -0.06 (-0.22–0.11) | 0.50 | 0.04 (-0.58–0.66) | 0.90 | -0.02 (-0.10–0.06) | 0.64 | -0.03 (-0.15–0.09) | 0.62 | 0.01 (-0.02–0.04) | 0.61 |
| 1p32.3 | rs11206510 | PCSK9 | 100 | 0.81 | -0.06 (-0.24–0.12) | 0.50 | 0.25 (-0.40–0.91) | 0.45 | 0.05 (-0.04–0.13) | 0.27 | 0.01 (-0.12–0.14) | 0.85 | 0.01 (-0.02–0.05) | 0.53 |
| 19p13.2 | rs1122608 | LDLR | 100 | 0.78 | -0.05 (-0.22–0.12) | 0.56 | 0.14 (-0.50–0.79) | 0.66 | 0.03 (-0.05–0.11) | 0.49 | 0.06 (-0.07–0.19) | 0.37 | 0.02 (-0.02–0.06) | 0.27 |
| 7q32.2 | rs11556924 | ZC3HC1 | 100 | 0.63 | -0.04 (-0.19–0.12) | 0.65 | 0.23 (-0.35–0.80) | 0.44 | 0.00 (-0.08–0.07) | 0.99 | -0.03 (-0.14–0.08) | 0.62 | 0.00 (-0.03–0.03) | 0.99 |
| 6q23.2 | rs12190287 | TCF21 | 100 | 0.65 | -0.13 (-0.28–0.03) | 0.10 | 0.00 (-0.58–0.57) | 0.99 | 0.02 (-0.05–0.10) | 0.52 | -0.02 (-0.14–0.09) | 0.70 | 0.01 (-0.02–0.04) | 0.59 |
| 10q24.3 | rs12413409 | CYP17A1 | 100 | 0.90 | -0.09 (-0.33–0.14) | 0.44 | 0.35 (-0.54–1.23) | 0.44 | -0.04 (-0.16–0.07) | 0.46 | -0.08 (-0.26–0.10) | 0.38 | 0.01 (-0.03–0.06) | 0.55 |
| 6p24.1 | rs12526453 | PHACTR1 | 99.9 | 0.69 | -0.05 (-0.20–0.10) | 0.53 | -0.12 (-0.69–0.45) | 0.67 | 0.04 (-0.04–0.11) | 0.33 | -0.01 (-0.12–0.10) | 0.87 | 0.02 (-0.01–0.05) | 0.29 |
| 17p11.2 | rs12936587 | RASD1. SMCR3. PEMT | 100 | 0.54 | 0.01 (-0.14–0.17) | 0.85 | 0.10 (-0.46–0.66) | 0.73 | -0.02 (-0.09–0.05) | 0.65 | -0.04 (-0.15–0.07) | 0.49 | 0.01 (-0.02–0.04) | 0.62 |
| 9p21.3 | rs1333049 | CDKN2BAS (ANRIL) | 99.9 | 0.51 | -0.06 (-0.21–0.08) | 0.40 | 0.15 (-0.38–0.69) | 0.58 | 0.01 (-0.06–0.08) | 0.83 | 0.07 (-0.04–0.17) | 0.21 | 0.00 (-0.03–0.03) | 0.92 |
| 10q23 | rs1412444 | LIPA | 99.9 | 0.34 | 0.00 (-0.15–0.14) | 0.98 | -0.25 (-0.79–0.30) | 0.38 | 0.00 (-0.07–0.07) | 0.92 | 0.01 (-0.10–0.12) | 0.89 | 0.02 (-0.01–0.05) | 0.22 |
| 2p11.2 | rs1561198 | VAMP5. VAMP8 | 100 | 0.48 | -0.05 (-0.19–0.09) | 0.47 | -0.58 (-1.10–-0.05) | 0.033 | -0.09 (-0.15–-0.02) | 0.014 | 0.00 (-0.11–0.10) | 1.00 | -0.02 (-0.05–0.01) | 0.12 |
| 1q41 | rs17465637 | MIA3 | 99.9 | 0.77 | -0.04 (-0.21–0.13) | 0.63 | -0.18 (-0.81–0.44) | 0.56 | 0.01 (-0.07–0.09) | 0.82 | -0.05 (-0.18–0.07) | 0.40 | 0.00 (-0.04–0.03) | 0.89 |
| 6p21.31 | rs17609940 | ANKS1A | 99.7 | 0.78 | 0.06 (-0.12–0.23) | 0.53 | 0.34 (-0.30–0.97) | 0.30 | -0.05 (-0.13–0.03) | 0.21 | 0.02 (-0.11–0.15) | 0.77 | -0.05 (-0.08–-0.02) | 0.0044 |
| 4q31.22 | rs1878406* | EDNRA | 100 | 0.15 | 0.20 (0.00–0.40) | 0.047 | -0.11 (-0.84–0.63) | 0.77 | 0.03 (-0.06–0.13) | 0.48 | 0.01 (-0.14–0.15) | 0.94 | -0.02 (-0.06–0.02) | 0.29 |
| 7p21.1 | rs2023938 | HDAC9 | 100 | 0.10 | 0.22 (-0.02–0.47) | 0.072 | 0.56 (-0.36–1.49) | 0.23 | -0.06 (-0.18–0.06) | 0.31 | 0.00 (-0.17–0.18) | 0.96 | 0.00 (-0.05–0.05) | 0.92 |
| 19q13 | rs2075650 | TOMM40, APOE | 99.9 | 0.17 | -0.37 (-0.56–-0.18) | 1.4×10−4 | -0.73 (-1.45–-0.02) | 0.046 | -0.06 (-0.15–0.03) | 0.19 | 0.05 (-0.10–0.19) | 0.54 | 0.00 (-0.04–0.04) | 0.94 |
| 17p13.3 | rs216172 | SMG6 | 99.7 | 0.38 | 0.00 (-0.15–0.15) | 0.99 | -0.02 (-0.44–0.40) | 0.93 | -0.04 (-0.11–0.03) | 0.26 | 0.06 (-0.05–0.17) | 0.31 | -0.03 (-0.06–0.00) | 0.061 |
| 2q22.3 | rs2252641 | ZEB2 | 100 | 0.48 | -0.11 (-0.26–0.04) | 0.14 | 0.30 (-0.26–0.85) | 0.30 | 0.01 (-0.06–0.08) | 0.75 | 0.05 (-0.06–0.16) | 0.38 | -0.02 (-0.05–0.01) | 0.20 |
| 10p11.23 | rs2505083 | KIAA1462 | 100 | 0.43 | 0.12 (-0.03–0.27) | 0.13 | 0.11 (-0.44–0.67) | 0.69 | 0.00 (-0.08–0.07) | 0.89 | 0.10 (-0.01–0.21) | 0.072 | -0.02 (-0.05–0.01) | 0.27 |
| 8p21.3 | rs264 | LPL | 99.6 | 0.86 | 0.16 (-0.05–0.38) | 0.13 | 0.40 (-0.20–1.00) | 0.19 | -0.03 (-0.13–0.07) | 0.54 | -0.05 (-0.20–0.10) | 0.53 | 0.04 (0.00–0.08) | 0.049 |
| 5q31.1 | rs273909 | SLC22A4 | 100 | 0.12 | -0.14 (-0.37–0.09) | 0.24 | -0.26 (-1.13–0.61) | 0.56 | -0.01 (-0.12–0.10) | 0.86 | -0.16 (-0.33–0.01) | 0.063 | 0.00 (-0.05–0.04) | 0.93 |
| 14q32.2 | rs2895811 | HHIPL1 | 99.9 | 0.47 | -0.02 (-0.17–0.12) | 0.76 | -0.32 (-0.73–0.10) | 0.13 | -0.01 (-0.08–0.06) | 0.79 | 0.03 (-0.08–0.14) | 0.55 | 0.01 (-0.02–0.04) | 0.69 |
| 8q24.13 | rs2954029 | TRIB1 | 100 | 0.52 | -0.14 (-0.29–0.01) | 0.061 | -0.40 (-0.95–0.14) | 0.15 | -0.05 (-0.12–0.02) | 0.18 | -0.04 (-0.15–0.07) | 0.50 | -0.01 (-0.04–0.02) | 0.49 |
| 12q24.12 | rs3184504 | SH2B3 | 99.0 | 0.56 | 0.01 (-0.13–0.16) | 0.89 | -0.25 (-0.78–0.28) | 0.35 | -0.05 (-0.12–0.02) | 0.16 | 0.00 (-0.10–0.11) | 0.93 | 0.00 (-0.03–0.03) | 0.96 |
| 6q25.3 | rs3798220 | LPA | 100 | 0.02 | 0.02 (-0.48–0.52) | 0.94 | -0.81 (-2.81–1.20) | 0.43 | -0.14 (-0.39–0.11) | 0.27 | -0.02 (-0.41–0.37) | 0.92 | -0.08 (-0.18–0.03) | 0.16 |
| 15q25.1 | rs3825807 | ADAMTS7 | 99.7 | 0.60 | 0.03 (-0.11–0.18) | 0.67 | 0.24 (-0.31–0.78) | 0.39 | -0.01 (-0.08–0.06) | 0.79 | 0.05 (-0.06–0.16) | 0.35 | 0.01 (-0.02–0.04) | 0.52 |
| 6p21.33 | rs3869109 | HLA-C. HLA-B | 99.7 | 0.59 | -0.09 (-0.23–0.05) | 0.22 | 0.18 (-0.35–0.71) | 0.50 | 0.06 (-0.01–0.12) | 0.10 | -0.10 (-0.21–0.00) | 0.062 | 0.02 (-0.01–0.04) | 0.29 |
| 17q21.32 | rs46522 | UBE2Z | 100 | 0.58 | -0.10 (-0.25–0.05) | 0.19 | -0.04 (-0.59–0.51) | 0.89 | 0.06 (-0.01–0.13) | 0.12 | 0.07 (-0.04–0.18) | 0.23 | 0.00 (-0.03–0.02) | 0.75 |
| 13q34 | rs4773144 | COL4A1 | 99.7 | 0.42 | 0.01 (-0.14–0.16) | 0.89 | -0.25 (-0.82–0.32) | 0.38 | -0.01 (-0.08–0.07) | 0.89 | 0.01 (-0.10–0.12) | 0.90 | -0.03 (-0.06–0.00) | 0.083 |
| 9q34 | rs495828 | AB0 | 99.7 | 0.23 | 0.09 (-0.08–0.26) | 0.29 | 0.40 (-0.23–1.03) | 0.21 | 0.01 (-0.07–0.09) | 0.87 | 0.00 (-0.13–0.12) | 0.98 | 0.01 (-0.02–0.05) | 0.46 |
| 10q11.1 | rs501120 | CXCL12 | 100 | 0.88 | -0.08 (-0.30–0.14) | 0.48 | -0.25 (-1.07–0.57) | 0.56 | 0.10 (-0.01–0.20) | 0.076 | -0.04 (-0.19–0.12) | 0.66 | 0.02 (-0.02–0.07) | 0.28 |
| 2p24.1 | rs515135 | APOB | 99.9 | 0.83 | 0.10 (-0.09–0.28) | 0.31 | 0.69 (-0.01–1.38) | 0.053 | 0.05 (-0.04–0.14) | 0.26 | -0.01 (-0.15–0.13) | 0.88 | -0.01 (-0.05–0.03) | 0.54 |
| 1p13 | rs599839 | SORT1 | 100 | 0.78 | 0.15 (-0.03–0.33) | 0.10 | 0.21 (-0.45–0.88) | 0.53 | 0.06 (-0.02–0.15) | 0.16 | 0.14 (0.01–0.28) | 0.034 | 0.01 (-0.02–0.05) | 0.54 |
| 2p21 | rs6544713 | ABCG8 | 100 | 0.30 | -0.04 (-0.20–0.12) | 0.62 | 0.06 (-0.53–0.66) | 0.83 | -0.05 (-0.12–0.03) | 0.22 | -0.02 (-0.13–0.10) | 0.80 | -0.01 (-0.04–0.02) | 0.54 |
| 2q33.1 | rs6725887 | WDR12 | 100 | 0.17 | -0.14 (-0.33–0.05) | 0.15 | 0.01 (-0.71–0.74) | 0.97 | 0.02 (-0.07–0.11) | 0.68 | -0.08 (-0.22–0.06) | 0.29 | 0.01 (-0.03–0.05) | 0.54 |
| 4q32.1 | rs7692387 | GUCY1A3 | 100 | 0.83 | -0.13 (-0.33–0.07) | 0.22 | 0.09 (-0.66–0.85) | 0.80 | 0.00 (-0.10–0.10) | 0.98 | -0.05 (-0.19–0.10) | 0.51 | -0.02 (-0.06–0.02) | 0.39 |
| 15q26.1 | rs8039305 | FURIN | 99.7 | 0.51 | -0.01 (0.16–0.13) | 0.85 | 0.27 (-0.28–0.82) | 0.33 | -0.01 (-0.08–0.06) | 0.87 | -0.03 (-0.14–0.08) | 0.56 | 0.03 (0.00–0.06) | 0.068 |
| 13q12.3 | rs9319428 | FLT1 | 99.7 | 0.33 | 0.00 (-0.15–0.16) | 0.96 | 0.24 (-0.33–0.82) | 0.41 | -0.03 (-0.11–0.04) | 0.37 | 0.00 (-0.11–0.12) | 0.95 | -0.01 (-0.04–0.02) | 0.66 |
| 11q22.3 | rs974819 | PDGFD | 100 | 0.27 | -0.04 (-0.20–0.12) | 0.62 | 0.18 (-0.42–0.79) | 0.55 | 0.03 (-0.05–0.11) | 0.45 | 0.02 (-0.10–0.14) | 0.75 | -0.02 (-0.05–0.01) | 0.24 |
| 21q22.1 | rs9982601 | MRPS6 | 99.9 | 0.14 | 0.14 (-0.07–0.35) | 0.18 | 0.22 (-0.57–1.01) | 0.59 | 0.06 (-0.04–0.16) | 0.24 | -0.02 (-0.17–0.14) | 0.84 | 0.03 (-0.01–0.07) | 0.16 |
Bold values indicate that the SNP meets a nominal threshold of significance of p<0.05.
*rs1878406 was genotyped as a C/T SNP.
Abbreviations: hs-CRP, high-sensitivity C-reactive protein; RAF, risk allele frequency; SNP, single nucleotide polymorphism.