Table 5. Summary of testing of NPW specimens collected during phase III LAIV trial in Bangladesh (samples collected from symptomatic cases within 2 weeks of vaccination).
| Study group | Type | Subtype/ lineage |
NPW specimens by real-time RT-PCR (n = 69) | NPW specimens by sequencing (n = 673) | ||||
|---|---|---|---|---|---|---|---|---|
| N positive1 | Ct value range | N positive4 | Vaccine-type | Wild-type | Inconclusive | |||
| LAIV | A | H1N1pdm | 11 | 18.17–34.08 | 12 | 0 | 12 | 0 |
| H3N2 | 36 | 21.56–38.85 | 37 | 37 | 0 | 0 | ||
| Unsubtyped | 3 | 35.87–38.18 | 2 | 2 | 0 | 0 | ||
| B | Yamagata | 292 | 25.26–39.75 | 36 | 36 | 0 | 0 | |
| Victoria | 0 | - | - | - | ||||
| Placebo | A | H1N1pdm | 9 | 19.72–27.66 | 9 | 0 | 9 | 0 |
| H3N2 | 0 | - | 0 | - | - | - | ||
| Unsubtyped | 0 | - | 0 | - | - | - | ||
| B | Yamagata | 0 | - | 0 | - | - | - | |
| Victoria | 0 | - | - | - | ||||
1co-infection with two viruses was detected in 19 subjects
2rRT-PCR protocol did not distinguish influenza B lineages
3Two NPW specimens positive by real-time PCR (Ct values 37.58, 35.7) were negative by RT-PCR
4co-infection of two or three viruses was detected in 23 subjects