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A) Density plot for healthy donor cfDNA sequencing reads mapped to 10kb genomic bins. A negative binomial (red) and Poisson (blue) distribution was fit to the resultant data. B) The ctDNA CNV size limit of detection (in megabases) is plotted as a function of sequencing depth for single copy change at various ctDNA fractions. C) Same as panel B but for four copies gained.
