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. 2017 Jul 7;12(7):e0180778. doi: 10.1371/journal.pone.0180778

Table 4. Inflammatory mediators associated with asthma control based on multivariate feature selection.

Selected Inflammatory Mediators
(direction of association with Difficult-to-Control asthma)1
TH17 associated
 TH2 associated
 Non TH2 or TH17
associated
• CXCL-1 (+)
• IL-8 (+)
• IL-17A (+)		 • IL-4 (-)
• IL-5 (+)
• IL-13 (-)		 • EGF (-)
• Eotaxin (-)
• IFN-γ (+)
• IL-1β (-)
• IL-12p40 (-)
• MDC (-)

1. + denotes cytokines associated with Difficult-to-Control disease,—denotes cytokines associated with Easy-to-Control asthma.