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. 2017 Jul 3;11:1989–2006. doi: 10.2147/DDDT.S136792

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© 2017 Feng et al. This work is published and licensed by Dove Medical Press Limited

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Effects of Sal on the liver function and histopathology of hepatic IRI mice.

Notes: (A) The ALT and AST levels increased dramatically in IRI mice at three time points. Pretreatment with Sal attenuated the increase of ALT and AST levels. The levels of serum ALT and AST changed depending on the Sal dosage and time. Data were given as mean ± SD (n=6, *P<0.05 for Sham versus IRI, ^#P<0.05 for IRI + Sal [10 mg/kg] versus IRI, and ^†P<0.05 for IRI + Sal [20 mg/kg] versus IRI + Sal [10 mg/kg]). (B) H&E stain of liver sections (original magnification, ×200).

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; H&E, hematoxylin and eosin; IRI, ischemia–reperfusion injury; Sal, salidroside.