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. 2017 Jun 30;13:821–830. doi: 10.2147/TCRM.S134581

Table 2.

Main results of the studies about the association of OA susceptibility with rs3740199

Study Allelic frequencies*
Genotypic distribution*
Odds ratios with 95% confidence intervals
Stratification analysis
C allele G allele CC GC GG C allele versus G allele CC versus GG GC + CC versus GG CC versus GG + GC
Poonpet et al6 214/192 186/208 56/46 102/100 42/52 1.25 (0.94–1.66) 1.57 (0.86–2.85) 1.34 (0.84–2.13) 1.29 (0.82–2.02) By gender
Shin et al12 658/1,563 792/1,911 147/350 364/863 214/524 0.99 (0.87–1.14) 1.01 (0.76–1.33) 1.03 (0.85–1.25) 1.01 (0.81–1.25) By gender
Kerna et al10 (TFOA part) 44/88 22/35 28/65 32/46 6/12 1.28 (0.52–4.35) 0.85 (0.29–2.49) 0.54 (0.17–1.75) 0.66 (0.36–1.20) By gender
Kerna et al10 (PFOA part) 70/62 27/30 53/41 34/43 10/8 1.16 (0.75–1.82) 1.01 (0.37–2.80) 0.83 (0.31–2.20) 1.50 (0.84–2.66) By gender
Rodriguez-Lopez et al11 (TKR part) NG NG NG NG NG 0.92 (0.81–1.05) NG NG NG By gender
Rodriguez-Lopez et al11 (THR part) NG NG NG NG NG 1.08 (0.96–1.21) NG NG NG By gender
Valdes et al9 NG NG NG NG NG NG NG 1.84 (1.22–2.79) NG None
Wang et al5 47.6%/49.0% 52.4%/51.0% 36/47 84/102 44/51 0.93 (0.76–1.14) 0.87 (0.48–1.61) 0.92 (0.58–1.49) 0.90 (0.54–1.52) None
Limer et al16 NG NG NG NG NG 1.01 (0.90–1.13) NG NG NG By hip and knee OA
Lou et al4 46.7%/49.4% 53.3%/50.6% 32/42 78/93 42/44 0.89 (0.65–1.22) 0.79 (0.41–1.50) 0.88 (0.53–1.46) 0.87 (0.52–1.47) None

Note:

*

Data are presented as case number/control number or case percentage/control percentage.

Abbreviations: TKR, total knee replacement; THR, total hip replacement; TFOA, tibiofemoral knee OA; PFOA, patellofemoral knee OA; NG, not given; OA, osteoarthritis.