Skip to main content
. 2017 Jun 22;13(6):e1005608. doi: 10.1371/journal.pcbi.1005608

Fig 3. LASSIM inferred a genome-wide model of 35,900 core-to-peripheral gene interactions.

Fig 3

(A) These peripheral genes do not have any feedbacks to the core system, nor any crosstalk among themselves. (B) The measured mRNA profiles of the 10,543 peripheral genes (blue/yellow represent relative low/high expression), sorted by the model cost (V(p*)) on the y-axis, and time points on the x-axis. As can be seen, genes that display a peak in expression at the second or third time points are generally associated with a higher cost. (C) The results from the ChIP-seq analysis of inferred to-gene interactions, where the y-axis shows the—log10(p). The red line denotes the significance level (Bootstrap P < 0.05).