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Tertiary structure comparison. Tertiary structures of PN-1 (PDB: 4DY7_C) and PEDF (PDB: 1IMV_A) were modeled on the Cn3D macromolecular structure viewer (Version 4.3). Alpha helices (pink) and beta sheets (blue) are highlighted. The 17mer region of PEDF (green) within alpha helix C exhibits neurotrophic activity. The corresponding peptide region in PN-1 is also shown in green. The dotted red line corresponds to the homologous serpin reactive center loop (RCL).
