Table 2. Pairwise comparison of the isolated CH/ZBD, 1B and helicase core domains of MERS-CoV nsp13, EAV nsp10 and Upf1 helicases.

Domain	Comparison	Dali Z-score	rmsd(Å)
CH/ZBD	nsp13 vs nsp10	4.4	3.4
	nsp13 vs Upf1	10.2	2.2
	nsp10 vs Upf1	3.0	3.5
1B	nsp13 vs nsp10	3.4	2.5
	nsp13 vs Upf1	2.8	3.3
	nsp10 vs Upf1	2.8	2.8
Helicase Core	nsp13 vs nsp10	23.2	2.7
	nsp13 vs Upf1	26.3	4.5
	nsp10 vs Upf1	20.9	3.6

nsp13: MERS-CoV nsp13, PDB ID: 5WWP

nsp10: EAV nsp10, PDB ID: 4N0N

Upf1: scUpf1 helicase, PDB ID: 2XZL