Table 1. Baseline Demographic and Clinical Characteristics.
ART=antiretroviral therapy, IQR=Interquartile range; Kruskal-Wallis test used for continuous variables and Fisher’s exact test used for categorical variables.
| Characteristic | Stably Unimpaired (N=25) | Worsening (N=22) | Stably Impaired (N=22) | Improving (N=20) | p-value |
|---|---|---|---|---|---|
| median (IQR)/N(%) | median (IQR)/N(%) | median (IQR)/N(%) | median (IQR)/N(%) | ||
| Age, years | 46.0 (38.0, 50.0) | 46.0 (40.0, 50.0) | 48.5 (41.0, 51.0) | 42.5 (37.5, 48.0) | 0.387 |
| Education, years | 13 (12, 15) | 12.5 (12, 14) | 13 (12, 16) | 12 (11, 16) | 0.875 |
| Sex (men) | 23 (92%) | 19 (86%) | 19 (86%) | 16 (80%) | 0.697 |
| Ethnicity (Caucasian) | 14 (56%) | 14 (64%) | 10 (45%) | 14(70%) | 0.613 |
| AIDS | 14 (56%) | 15 (68%) | 17(77%) | 17(85%) | 0.180 |
| HCV seropositive | 4 (16%) | 3 (14%) | 6 (27%) | 4 (20%) | 0.727 |
| Current CD4 count, cells/mm3 | 462 [312, 663] | 339 [189, 425] | 499.5 [370, 712] | 170.5 [101, 484] | 0.003 |
| Nadir CD4 count, cells/mm3 | 190 [102, 322] | 60 [18, 234] | 120 [41, 209] | 33 [7, 147] | 0.030 |
| ART Use | 19 (76%) | 14 (64%) | 19 (86%) | 15 (75%) | 0.231 |
| Among those taking ART | |||||
| Duration of current ART regimen, months | 9.2 [4.6, 31.2] | 9.6 (4.6, 24.6) | 10.9 (5.8, 37.9) | 11.8 (2.0, 29.5) | 0.876 |
| Plasma viral load ≤ 50 copies/mL | 10 (59%) | 8 (57%) | 12 (71%) | 3 (23%) | 0.072 |
| CSF viral load, ≤ 50 copies/mL | 14 (93%) | 11 (79%) | 15 (88%) | 11 (85%) | 0.754 |