Table 3. CSF proteins showing increases (left), and decreases (right) in abundance during cognitive improvement (right).

Benjamini-Hochberg corrected p-value from paired two tailed t-test.

Protein	p-value	Up	Protein	p-value	Down
Regulation of Protein Folding and Proteolysis			Lipolysis
Clusterin	0.037885	↑	Zinc-alpha-2-glycoprotein	0.00088	↓
Vitronectin	0.003026	↑	Plasma Transport
Alpha-1-antitrypsin	0.000185	↑	Vitamin D-binding protein	0.000001	↓
Plasma protease C1 inhibitor	0.000001	↑	Beta-2-glycoprotein 1	0.006946	↓
Alpha-1-antichymotrypsin	0.015667	↑	Alpha-1B-glycoprotein	0.000035	↓
Alpha-2-microglobulin	0.041462	↑	Ceruloplasmin	0.051851	↓
Beta-Ala-His didpeptidase	0.000896	↑	Afamin	0.048041	↓
Cystatin C	0.003981	↑	Apolipoprotein D	0.052998	↓
Gelsolin	0.0203	↑	Apolipoprotein A-II	0.000035	↓
Plasma Transport			Serotransferrin	0.000000000068	↓
Transthyretin	0.000017	↑	Alpha-1-acid glycoprotein 2	0.000035	↓
Lipid Metabolism and Transport			Alpha-2-HS-glycoprotein	0.003551	↓
Apolipoprotein E	0.000243	↑	Haptoglobin	0.000744	↓
Apolipoprotein A-I	0.000248	↑	Haptoglobin-related protein	0.020599	↓
Apolipoprotein A-IV	0.000035	↑	Neurite Outgrowth
Neuronal Development and Neurotrophic Functions			Neural cell adhesion molecule 1	0.00882	↓
Neuronal cell adhesion molecule	0.00882	↑	Prostaglandin-H2 D-isomerase	0.020458	↓
Pigment epithelium-derived factor	0.000896	↑	Amyloid beta A4 protein	0.003981	↓
Amyloid-like protein 1	0.003981	↑	Immune and Acute Phase Response
Neuroendocrine Signaling
Angiotensinogen	0.000185	↑	Beta-2-microglobulin	0.001393	↓
Chromogranin-A	0.003375	↑	Ig gamma-1 chain C region	0.017997	↓
Immune Regulation			Complement factor H	0.003981	↓
Complement C4-A	0.001569	↑	Alpha-1-acid glycoprotein 1	0.000001	↓
Complement C4-B	0.001615	↑	RNA Degradation
Complement C3	0.036589	↑	Ribonuclease pancreatic	0.009935	↓
Complement C1s subcomponent	0.000195	↑
Glycosylation
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase	0.00128	↑