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. 2017 Jul 7;7:4880. doi: 10.1038/s41598-017-05033-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Constitutive activation of the NLRP3 inflammasome in myeloid cells causes anemia of inflammation through IL-1 signaling. All data were obtained from 2-week old WT or mutant male mice. (A–E) Cell blood counts (n = 4 mice/genotype). WBC, white blood cell counts, RBC, red blood cell counts. (F) Bone marrow cells (n = 4 mice/genotype) were stained with isotype control (data not shown) or with antibodies against CD11b and Ter119. Representative flow cytometry dot plots of CD11b⁺ myeloid cells or Ter119⁺ erythrocytes from each genotype are shown. (G) The percentage of Ter119⁺ erythrocytes in bone marrow cells. Data are expressed as mean ± SEM. *P < 0.05; **P < 0.005. (H) Body weight. (I) Spleen weight. (J) Percent of spleen weight (spleen weight was normalized to body weight). Quantitative data (H–J) were obtained from 5–6 mice/genotype and expressed as the mean ± SEM. *P < 0.05; **P < 0.005. (K) Body weight. (L) Spleen weight. (M) Percent of spleen weight. Quantitative data (K–M) were obtained from 3–5 mice/genotype and expressed as the mean ± SEM. **P < 0.005. NS, not significant.