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. 2017 Jul 7;7:4845. doi: 10.1038/s41598-017-04936-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptomic profile of of hth + tsh cells. (A) Gene Ontology enrichment of genes up-regulated in hth + tsh compared to control eye discs (EA). Analysis performed by GOrilla⁹⁷ on a ranked list of genes sorted by (signed) −log10(p-value). The sign indicates that up-regulated genes are on top (logFC > 0) and down-regulated genes (logFC < 0) are on the bottom of the list. (B) Heatmap with row-normalized expression values of the most significantly up-regulated cell-cycle related genes. (C) Motif enrichment on the up-regulated genes (770 genes, selected as the “leading edge” of the GOrilla analysis for cell cycle enrichment). Enrichment analysis is performed by i-cisTarget³³ and enriched motifs are clustered within i-cisTarget using STAMP¹⁰³. NES = Normalized Enrichment Score (>2.5 is significant). The Hth motif was not found enriched. (D) Heat map of expression profiles of motif related Nuclear Receptor genes and Blimp-1, showing strongest up-regulation of EcR and ftz-f1, and strongest down-regulation of Hr46 and Blimp-1.