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. 2017 Jul 7;7:4845. doi: 10.1038/s41598-017-04936-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Co-expression of hth + tsh downregulate EcR signaling. hth + tsh-expressing clones (marked with GFP) induced in an Ecdysone Response Element-lacZ (EcRE-Z) background analyzed in L3 eye discs. lacZ expression is monitored with an anti-β galactosidase antibody (β gal). EcRE-Z is expressed straddling the morphogenetic furrow (dashed line) exclusively (A,A’). hth + tsh-clones overlapping the EcRE-Z domain repress its expression (B), while clones elsewhere do not (A,A’). (A) is a lower magnification view of the disc shown in (A’) where the whole pattern of EcRE-Z can be seen. The EcRE-Z sinla is shown separately in the lower panels.