Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 7;7:4845. doi: 10.1038/s41598-017-04936-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Altering Hr46 and ftz-f1 expression regulates proliferation of eye progenitors. L3 eye discs of the indicated genotypes (A–D) stained for cyclinB (cycB, green) and the mitotic marker PH3 (red). Merged and cycB signals are shown. Control discs are optix>+. PH3-positive cells were counted in the anterior region of the eye disc, where undifferentiated progenitors reside (outlined in white in A). In (A’) the double-headed arrow marks the width of the G1-arrested domain (see text for details). (E) Statistical analysis of the mitotic density (PH3 + cells/anterior area) indicates that overexpression of Hr46 and RNAi-mediated attenuation of ftz-f1 result in increased proliferation. Note that in both genotypes the G1 arrested domain is narrower than in the control (especially for optix > Hr46; B). On the contrary, overexpression of ftz-f1 results in reduced proliferation.