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. 2017 Jul 7;7:4852. doi: 10.1038/s41598-017-04941-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative ROI placements. (a) To measure manganese uptake in the auditory system, ROIs were placed in the left and right dorsal cochlear nuclei (DCNs), ventral cochlear nuclei (VCNs), central nuclei of the inferior colliculus (CICs), external cortices of the inferior colliculus (ECICs), dorsal cortices of the inferior colliculus (DCIC), medial geniculate bodies (MGBs), and auditory cortices (ACs). ROIs were also placed in the left and right anterior pituitary glands and nearby noise. (b) To measure the limbic system, ROIs were placed in the left and right centromedial amygdala (AMG_C), the superficial/cortical-like amygdala (AMG_S), deep/basolateral amygdala complex (AMG_D), nucleus accumbens core (NA_C) and shell (NA_S), and anterior cingulate cortices (ACCs). (c) To measure the hippocampus, four rectangular bands (white color) were first placed onto the PDGE image. They were then copied onto the corresponding MPRAGE image.