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. 2017 Jul 7;7:4914. doi: 10.1038/s41598-017-04895-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association of TRAF6 haplotypes with SBP and survival. (A) Combined prospective and retrospective analysis. Frequency of SBP in patients stratified for the presence of the TRAF6 risk haplotype 2 (HT2) and other haplotypes (non-risk HTs). The frequency of SBP is given for SBP, which were well documented at baseline (history of SBP) and, which were diagnosed at inclusion or during follow-up. P value from Fisher’s exact test. (B) Prospective analysis. The cumulative incidence of a first episode of SBP in patients without a history of SBP and without SBP at inclusion is indicated and stratified for the presence of the TRAF6 risk haplotype 2. Data were right-censored at liver transplantation, death, or loss-to-follow-up. Patients at risk and the P value from log-rank test are indicated. (C) The frequency of SBP in patients stratified for the presence of the TRAF6 risk haplotype 2 (HT2) and other haplotypes (non-risk HTs) is given for patients carrying at least one of the NOD2 risk variants R702W, G908R or L1007fs and for patients with the NOD2 wild-types. P values from Fisher’s exact test. (D) Kaplan-Meier analysis of cumulative survival of the overall cohort is shown and stratified for the presence of the TRAF6 risk haplotype 2. Data were right-censored at liver transplantation or loss-to-follow-up. Patients at risk and the P value from log-rank test are indicated.