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. 2017 Jul 7;7:4914. doi: 10.1038/s41598-017-04895-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association of TRAF6 haplotypes with peritoneal immune activation. (A) Concentrations of soluble urokinase-type plasminogen activator receptor (suPAR) in non-infected ascites are shown for the different TRAF6 haplotypes. (B–D) mRNA expression of TRAF6, IL-6 and CXCL8 in freshly isolated peritoneal macrophages are shown for the respective TRAF6 haplotypes and were expressed relative to the housekeeping gene ß-actin. (E) Nuclear concentrations of active NF-κB p65 in freshly isolated peritoneal macrophages are shown for the respective haplotypes. (F) Quantification of CXCL8 in supernatants from cultivated primary peritoneal macrophages, which were left unstimulated or were stimulated with LPS (10 ng/ml) for 24 hours. All data are expressed as boxplots (min to max). Non-risk haplotypes (HTs) including HT1, HT3 and the mixed haplotype are indicated (right panels) and were pooled and compared to the risk haplotype HT2 (left panels). Numbers of analyzed samples are indicated. P values indicate differences between HT2 and non-risk HTs in Mann-Whitney U test. n.s.: not significant.