Table 4.
Risk factors for death.
| Hazard ratio (95% CI) | P-value | |
|---|---|---|
| (a) Unadjusted Cox proportional hazard model | ||
| Age* (per 1-year increase) | 1.03 (1.02–1.05) | <0.001 |
| Male sex | 1.07 (0.79–1.44) | 0.68 |
| Child Pugh C* | 1.70 (1.24–2.32) | <0.001 |
| MELD* (per 1-point increase) | 1.06 (1.04–1.08) | <0.001 |
| Hepatocellular carcinoma* | 2.42 (1.72–3.41) | <0.001 |
| SBP at any time | 1.54 (1.15–2.06) | 0.004 |
| NOD2 risk variant# | 0.94 (0.66–1.35) | 0.75 |
| TRAF6 risk haplotype 2 | 0.82 (0.59–1.15) | 0.26 |
| Use of beta blockers* | 0.93 (0.70–1.23) | 0.93 |
| (b) Multivariate Cox proportional hazard model | ||
| Age* (per 1-year increase) | 1.04 (1.02–1.05) | <0.001 |
| Child Pugh C* | Removed from model | n.s. |
| MELD* (per 1-point increase) | 1.07 (1.05–1.09) | <0.001 |
| Hepatocellular carcinoma* | 2.43 (1.71–3.46) | <0.001 |
| SBP at any time | 1.67 (1.25–2.24) | <0.001 |
*At inclusion. #Risk variants R702W, G908R and L1007fs.
Abbreviations: confidence interval (CI), spontaneous bacterial peritonitis (SBP), tumor necrosis factor receptor-associated factor 6 (TRAF6), model for end-stage liver disease (MELD), nucleotide-binding oligomerization domain containing 2 (NOD2), not significant (n.s.).