Table 1.
Baseline characteristics of the primary hyperparathyroidism (PHPT) and normal control groups.
| Baseline Variables | Normal controls (n = 50) | PHPT | |
|---|---|---|---|
| Normal calcium (n = 19) | Hypercalcaemia (n = 153) | ||
| Age (years) | 45.5 ± 4.6 | 59.1 ± 14.3* | 55.3 ± 16.0# |
| Sex male (%) | 60.0 | 26.3 | 21.6# |
| BMI (kg/m2) | 24.7 (23.3–26.9) | 25.4 (23.7–25.4) | 23.1 (23.1–24.1)#‡ |
| SBP (mmHg) | 121 (111.8–126.5) | 132.0 (128.0–142.0)* | 126.0 (116.0–132.0)‡ |
| DBP (mmHg) | 75.0 (68.8–83.3) | 76.0 (70.0–80.0) | 77.0 (70.0–80.0) |
| Hb | 146.0 (135.5–158) | 129.0 (124.0–141.0)*† | 125.0 (114.0–133.5)#‡ |
| ALT (U/L) | 23.5 (13.8–27.5) | 16.0 (13.0–21.0) | 16.0 (12.0–23.0)# |
| AST (U/L) | 22.5 (19.0–26.0) | 19.0 (15.0–22.0) | 20.0 (16.0–24.0) |
| ALP (U/L) | 61.5 (55.8–76.3) | 107.0 (74.0–269.0)*† | 114.0 (79.5–289.5)#‡ |
| Sodium (mmol/L) | 140.0 (138–141.3) | 142.5 (140.0–144.0)*† | 142.0 (141.0–144.0)#‡ |
| Potassium (mmol/L) | 4.1 (4.0–4.3) | 4.1 (3.9–4.3) | 4.2 (3.9–4.4) |
| Calcium (mmol/L) | 2.4 (2.3–2.4) | 2.6 (2.5–2.6)* | 2.8 (2.7–3.0)#‡ |
| Phosphorus (mg/dL) | 3.3 (3.0–3.6) | 2.9 (2.4–3.4)* | 2.6 (2.2–3.0)# |
| Chloride (mmol/L) | 98.5 (97.0–100.0) | 106.0 (104.0–107.0)*† | 107.0 (105.0–109.0)#‡ |
| Cl/PO4 | 29.9 (27.6–32.3) | 33.9 (31.7–43.0)*† | 43.1 (37.0–47.5)#‡ |
| PTH (ng/L) | 41.7 (35.0–47.8) | 179.5 (131.7–435.5)*† | 416.5 (153.2–560.6)#‡ |
Data are the means ± SD or medians (interquartile range). *P < 0.05 NPHPT subjects vs. normal controls; † P < 0.05 NPHPT subjects vs. normal controls after adjusting for age and sex; # P < 0.05 hypercalcaemic PHPT group vs. normal controls; ‡ P < 0.05 hypercalcaemic PHPT group vs. normal controls after adjusting for age and sex. BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; Hb, haemoglobin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; PTH, parathyroid hormone; Cl/PO4, chloride/phosphorus ratio.