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. 2017 Jul 7;7:4923. doi: 10.1038/s41598-017-04968-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of fluvoxamine on NSC viability and neurosphere formation in vitro. (A) The number of viable cells was evaluated using MTT assay. Fluvoxamine increased the number of viable cells as compared to the control group. Each bar represents the mean value of absorbance at 460 nm. (B) Representative images of neurospheres in the different groups. Scale bar = 100 μm (C) Fluvoxamine significantly increased neurosphere formation at 1, 5, and 50 nM, while it was toxic at 500 nM. (D) Cell counts obtained from neurospheres showed an increase of the mean cell number at 1, 5 and 50 nM. Data were expressed as mean ± SEM and each experiment included 15 replicates per condition (n = 15).