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. 2017 Jul 7;7:4923. doi: 10.1038/s41598-017-04968-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of fluvoxamine on eNSC differentiation to glial and oligodendrocyte cells. (A) Representative immunofluorescence images of differentiated embryonic NSCs stained with GFAP (Glial Fibrillary Acidic Protein, an astrocyte marker, red) or MBP (Myelin Basic Protein, an oligodendrocyte marker, green) and Hoechst (a nuclei marker, blue) in control, and treated groups at day 6. White scale bars indicate 100 𝜇m. (B,C) Quantification of the frequency of GFAP and MBP positive cells in treated groups, normalized to the control group. Results showed that fluvoxamine at 1 and 5 nM concentrations are optimal for differentiation to MBP and GFAP positive cell, respectively. Each group included 3 replicates (n = 3). Values are presented as mean ± SEM for 15 field/well. Statistical analyses were performed by one-way analysis of variance followed by Tukey test. *p < 0.05; **p < 0.01; ***p < 0.001 and ****p < 0.0001.