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. 2017 Jul 7;7:4923. doi: 10.1038/s41598-017-04968-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Administration of fluvoxamine ameliorated experimental autoimmune encephalomyelitis (EAE) clinical outcomes. EAE was induced in Lewis rats (day 0) which were treated at day 12 (scores > 2) with fluvoxamine (50 mg/kg) i.p. for 6 subsequent days. Daily clinical scores were measured from day 10 to day 17 in fluvoxamine and vehicle groups. Each group contained 7 rats. Data are expressed as mean ± SEM.