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. 2017 Jul 7;7:4923. doi: 10.1038/s41598-017-04968-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Concentrations of cytokines in serum samples using enzyme-linked immunosorbent assay. (A) IL-4 anti-inflammatory cytokine and (B) IFN-γ pro-inflammatory cytokine levels were measured in all rats on day 17. Fluvoxamine significantly reduced the levels of IL-4, while increasing the levels of IFN-γ, compared to EAE controls (p < 0.001 and p < 0.0001, respectively). (G) Ratio of IFN-γ/IL-4. Values represent the mean ± SEM. ***p < 0.001, ****p < 0.0001.