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. 2017 Jul 7;7:4872. doi: 10.1038/s41598-017-05137-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ex-vivo vessels culture at t3: A740003 effects on IL1β. IL-1β content in PL tissues and culture supernatants after treatment with A740003 at t3 are shown (A). IL-1β content in a subset of PLs which fragments were treated for 24 h (t1) and 72 h (t3) with A740003 are shown. Points with before–after connecting lines and letters indicate fragments from the same vessel. (B). Quantification of proIL-1β by OD densitometric analysis in PLs treated with A740003 at t3 (C, left) and a representative cropped western blot of P2X7-machinery (C, right) are shown. Densitometry of P2X7 isoforms at 75 kD and 54 kD in PLs treated with A740003 at t3 is in (D) with representative cropped western blot in the inset. Values displayed as boxes are presented with 5–95 percentile. Paired t-test is used; significant difference is shown as *p < 0.05.