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. 2017 Jul 7;7:4872. doi: 10.1038/s41598-017-05137-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ex-vivo vessels culture: A740003 effects on MMP9 content and activities. MMP9 content in PL extracts after treatment with A740003 is displayed (A). Paired t-test is applied. Quantification of MMP9-related gelatinolytic activities in PL extracts after treatment with A740003 at t1 and t3 is plotted (B). Wilcoxon signed rank test is applied. MMP9-related gelatinolytic activities in IMA extracts are presented (C) as scatter dot plot with median and interquartile range. A740003 on patients grouped for their smoking status: efficacy in diminishing the MMP9 content and activities is shown (D). Dotted line displays the control value in (D) histograms. One-way ANOVA with Bonferroni post-hoc test is used. Values displayed as boxes are shown with whiskers 5–95 percentile. Significant differences are shown as *p < 0.05, **p < 0.01 and ***p < 0.001.