Table 3.
Changes in dietary intake and follow-up IGF level, adjusted for baseline IGF
| n | Mean change in intake | Mean follow-up intake | Mean follow-up IGFa | Difference (95% CI) in mean follow-up serum IGF concentration (%) | ||
|---|---|---|---|---|---|---|
| Model 1b | Model 2c | |||||
| IGF-I (n = 619) | ||||||
| Total energy (kcal/day) | ||||||
| No change | 309 | −13.5 | 2294.8 | 20.3 | Ref | Ref |
| Decreased | 156 | −649.3 | 1955.1 | 20.3 | −1.2 (−7.0, 4.6) | −1.7 (−7.5, 4.1) |
| Increased | 154 | 661.3 | 2602.7 | 20.8 | 4.3 (-1.5, 10.2) | 4.3 (-1.6, 10.1) |
| Total protein (g/day) | ||||||
| No change | 325 | 0.0 | 86.6 | 20.8 | Ref | Ref |
| Decreased | 158 | −26.6 | 75.8 | 19.5 | −6.5 (−12.9, −0.2) | −6.5 (−12.8, −0.3)* |
| Increased | 136 | 25.4 | 102.2 | 20.5 | 3.7 (−2.9, 10.2) | 4.5 (−2.0, 11.1) |
| Dairy protein (g/day) | ||||||
| No change | 351 | −0.3 | 15.5 | 20.2 | Ref | Ref |
| Decreased | 160 | −7.4 | 11.9 | 21.0 | 3.3 (−2.3, 9.0) | 4.1 (−1.5, 9.7) |
| Increased | 108 | 7.0 | 19.1 | 20.1 | −0.2 (−6.7, 6.4) | 0.2 (−6.3, 6.7) |
| Dairy productsd (g/day) | ||||||
| No change | 372 | −10.2 | 360.1 | 20.5 | Ref | Ref |
| Decreased | 148 | −181.2 | 274.7 | 19.8 | −2.3 (−8.1, 3.4) | −2.2 (−7.8, 3.5) |
| Increased | 99 | 179.3 | 462.3 | 20.7 | 2.5 (−4.2, 9.1) | 2.0 (−4.6, 8.6) |
| IGFBP-3 (n = 607) | ||||||
| Total energy (kcal/day) | ||||||
| No change | 301 | −10.0 | 2304.7 | 130.6 | Ref | Ref |
| Decreased | 154 | −648.4 | 1952.4 | 133.9 | 2.7 (−2.7, 8.2) | 2.8 (−2.7, 8.2) |
| Increased | 152 | 660.8 | 2601.1 | 130.3 | 0.4 (−5.1, 5.9) | 0.6 (−5.0, 6.1) |
| Total protein (g/day) | ||||||
| No change | 320 | 0.2 | 86.8 | 133.0 | Ref | Ref |
| Decreased | 157 | −26.4 | 75.9 | 129.4 | −2.2 (−8.2, 3.7) | −2.3 (−8.3, 3.7) |
| Increased | 134 | 25.6 | 102.1 | 129.7 | −2.2 (−8.4, 4.0) | −2.0 (−8.3, 4.2) |
| Dairy protein (g/day) | ||||||
| No change | 344 | −0.3 | 15.4 | 130.1 | Ref | Ref |
| Decreased | 156 | −7.4 | 12.0 | 131.5 | 1.8 (−3.6, 7.1) | 2.0 (−3.3, 7.4) |
| Increased | 107 | 7.0 | 19.1 | 135.3 | 3.1 (−3.0, 9.2) | 3.0 (−3.1, 9.2) |
| Dairy productsd (g/day) | ||||||
| No change | 367 | −11.0 | 360.7 | 130.7 | Ref | Ref |
| Decreased | 143 | −183.8 | 274.3 | 128.3 | −0.4 (−5.8, 5.0) | −0.3 (−5.7, 5.1) |
| Increased | 97 | 180.0 | 461.9 | 138.4 | 5.3 (−0.9, 11.5) | 5.2 (−1.1, 11.4) |
aMean predicted from fully adjusted regression model (nmol/mL)
bAdjusted for baseline age, baseline IGF, baseline dietary intake, follow-up time point, and changes in energy intake (except that for total energy)
cFurther adjusted for treatment received and cancer grade
dFor definition of dairy products, refer to Supplementary Material 1. * p = 0.04