Table 3.

Association of Individual Patient Factors with Odds of Favorable Change in Overall Urinary Bother from Pre- to 2 years Post-Treatment after Primary Prostate Cancer Treatment^*

Variable	Odds Ratio	95% CI	p-value
Pre-treatment urinary medication usage	1.4	1.0 – 2.0	0.04
Moderate to severe pre-treatment LUTS†	2.8	2.2 – 3.6	<0.001
In RP subjects	4.3	3.0 – 6.1	<0.001
In XRT subjects	1.9	1.1 – 3.0	0.01
In BT subjects	1.9	1.1 – 3.1	0.01
Pre-treatment urinary incontinence††	1.2	0.8 – 1.7	0.39
Cohabitation	0.8	0.6 – 1.0	0.07
2 or more comorbidities	0.8	0.6 – 1.1	0.13
Body mass index > 35	0.7	0.5 – 1.0	0.08

^*The Odds Ratios were computed based by the multivariable ordinal logistic regression model as described in Methods. The following covariates were also assessed, but were not statistically significant, nor suspected to be confounders: age, cohabitation, race, education, D’Amico risk group, prostate size, and use of hormonal therapy. Potential confounders were retained the model, even if not statistically significant.

^†Defined as AUA-SI¹ score ≥ 8. Effect modification was present between moderate-severe pre-treatment LUTS and treatment group (p = 0.003). The reported odds ratio of 2.8 is without an interaction term present.

^††Defined as EPIC-26 urinary incontinence score ≤ 70