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. 2016 Jul 2;53(1):87–104. doi: 10.1007/s12016-016-8574-3

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Evolving autoantibody (autoAb) testing and strategies for the serological diagnosis of systemic autoimmune rheumatic diseases. ANA antinuclear antibody, autoAb autoantibody, CIE counterimmunoelectrophoresis, D/LIA dot/line immunoassay, ELISA enzyme-linked immunosorbent assay, ENA extractable nuclear antigen, IB immunoblot/westernblot, ID/DRID immunodiffusion/double radial immunodiffusion, IIF indirect immunofluorescence, IP immunoprecipitation, MIA microbead immunoassay, RIP radioimmunoprecipitation